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This high-risk game has a Pay Anywhere feature which rewards players with winnings when they get eight or more matching symbols on the reels. This game also comes with a Free Spins bonus with multipliers that can be as high as 500x your stake. A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for a pragmatic trial to be reliable and reduce bias in results is also essential. Too much heterogeneity, however, can cause problems with the design of the trial. Pragmatic Play is a major player on the live casino market offers various classic table games like Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic experience in gambling as well a full variety of betting options via virtual. 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The games offered by the company are protected by high-end encryption, and its security team is on hand to assist players with any issues. Pragmatic Play's slot games are a hit among both newcomers and seasoned players. They have modern graphics and traditional themes. They offer a range of paylines and bonus rounds, and many offer progressive jackpots. They are also not particularly volatile, so you can expect to have a long-lasting gaming session with them. Most Pragmatic Play games are available for free, so you can play them before you decide to play them with real money. These free games are designed to run on all kinds of devices from tablets to desktops and smartphones. You can play them anywhere you have an internet connection. They are easy to navigate. Some Pragmatic Play websites even let you test your luck while in motion by using a practice mode. This will allow you to familiarize yourself with game rules and features prior to playing for real money. Legality Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. The software is available on mobile devices and in multiple languages. Despite its infancy it has established itself as a premier casino gaming platform. Its latest releases include Wolves which is a five-reel video slot with a healthy RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat. Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be used to determine the causal relationship between an intervention with its outcomes. They should, however, not, be used to replace the need for explanation studies. The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a practical trial which includes the recruitment process, the design and implementation of the intervention, and follow-up. The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.